Social Behavioral Deficits with Loss of Neurofibromin Emerge from Peripheral Chemosensory Neuron Dysfunction.

ABSTRACT: Neurofibromatosis type 1 (NF1) is a neurodevelopmental disorder associated with social and communicative disabilities. The cellular and circuit mechanisms by which loss of neurofibromin 1 (Nf1) results in social deficits are unknown. Here, we identify social behavioral dysregulation with Nf1 loss in Drosophila. These deficits map to primary dysfunction of a group of peripheral sensory neurons. Nf1 regulation of Ras signaling in adult ppk23⁺ chemosensory cells is required for normal social behaviors in flies. Loss of Nf1 attenuates ppk23⁺ neuronal activity in response to pheromones, and circuit-specific manipulation of Nf1 expression or neuronal activity in ppk23⁺ neurons rescues social deficits. This disrupted sensory processing gives rise to persistent cha

SUBMITTER: Moscato EH 

PROVIDER: S-EPMC7416787 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature