Intratumoral collagen signatures predict clinical outcomes in feline mammary carcinoma.

ABSTRACT: Breast cancer is the most common cause of cancer-related deaths in women worldwide. Identification of reliable prognostic indicators and therapeutic targets is critical for improving patient outcome. Cancer in companion animals often strongly resembles human cancers and a comparative approach to identify prognostic markers can improve clinical care across species. Feline mammary tumors (FMT) serve as models for extremely aggressive triple negative breast cancer (TNBC) in humans, with high rates of local and distant recurrence after resection. Despite the aggressive clinical behavior of most FMT, current prognostic indicators are insufficient for accurately predicting outcome, similar to human patients. Given significant heterogeneity of mammary tumors, there has been a recent focus on iden

SUBMITTER: Rosen S 

PROVIDER: S-EPMC7416937 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature