Browse
Submit Data
Databases
API
Help

Dataset Information

13 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Cerebrospinal fluid findings in COVID-19 patients with neurological symptoms

ABSTRACT: Highlights • Largest cohort of patients with COVID-19 and neurological symptoms who underwent LP.• In all 30 cases, RT-PCR for SARS-CoV-2 from CSF was negative.• CSF analysis findings, including WBC, were normal in most patients with COVID-19.• Neurological symptoms in COVID-19 seem to be caused mainly by indirect mechanism.

SUBMITTER: Neumann B

PROVIDER: S-EPMC7417278 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Similar Datasets

Characterizing cerebrospinal fluid immunity in neurological manifestations of COVID-19

Project description:Patients suffering from Coronavirus disease 2019 (COVID-19) can develop neurological sequelae, such as headache, neuroinflammatory or cerebrovascular disease. These conditions - here termed Neuro-COVID - are more frequent in patients with severe COVID-19. To understand the etiology of these neurological sequelae, we utilized single-cell sequencing and examined the immune cell profiles from the cerebrospinal fluid (CSF) of Neuro-COVID patients compared to patients with non-inflammatory and autoimmune neurological diseases or with viral encephalitis. The CSF of Neuro-COVID patients exhibited an expansion of dedifferentiated monocytes and of exhausted CD4+ T cells. Neuro-COVID CSF leukocytes featured an enriched interferon signature; however, this was less pronounced than in viral encephalitis. Repertoire analysis revealed broad clonal T cell expansion and curtailed interferon response in severe compared to mild Neuro-COVID patients. Collectively, our findings document the CSF immune compartment in Neuro-COVID patients and suggest compromised antiviral responses in this setting.

2020-12-11 | GSE163005 | GEO

Next-Generation Sequencing and Proteomics of Cerebrospinal Fluid From COVID-19 Patients With Neurological Manifestations.

Project description: Not available

| S-EPMC8695435 | biostudies-literature

Cerebrospinal fluid findings in patients with psychotic symptoms-a retrospective analysis.

Project description: Not available

| S-EPMC8010098 | biostudies-literature

Proteomics of Cerebrospinal fluid from COVID-19 Patients with Neurological Manifestations

Project description:We reported a case series of 8 patients with prominent new-onset neurological manifestations, who were screened out from a patch of 304 COVID-19 confirmed patients. Proteomics were conducted in the simultaneously obtained CSF and serum samples of the enrolled patients, with three non-COVID-19 patients with matched demographic features used as the controls for proteomic analysis.

2021-11-15 | PXD029740 | iProX

Characterizing cerebrospinal fluid immunity in neurological manifestations of COVID-19

Project description:Characterizing cerebrospinal fluid immunity in neurological manifestations of COVID-19

| PRJNA684320 | ENA

Cerebrospinal fluid findings in COVID-19: a multicenter study of 150 lumbar punctures in 127 patients.

Project description: Not available

| S-EPMC8771621 | biostudies-literature

Human gut microbiota, COVID-19 patients with mild or severe symptoms.

Project description:Analysis of COVID-19 hospitalized patients, with different kind of symptoms, by human rectal swabs collection and 16S sequencing approach.

2022-09-22 | E-MTAB-12236 | biostudies-arrayexpress

Neurological Manifestations of COVID-19 Feature T Cell Exhaustion and Dedifferentiated Monocytes in Cerebrospinal Fluid.

Project description: Not available

| S-EPMC7831653 | biostudies-literature

Cerebrospinal fluid findings in patients with seizure in the setting of COVID-19: A review of the literature.

Project description: Not available

| S-EPMC8127527 | biostudies-literature

Human Polyomaviruses in the Cerebrospinal Fluid of Neurological Patients.

Project description: Not available

| S-EPMC7022863 | biostudies-literature