Harnessing Natural Killer Cell Innate and Adaptive Traits in HIV Infection.

ABSTRACT: Despite efficient virological suppression on antiretroviral therapy (ART), people living with HIV (PLWH), experience an increased burden of premature co-morbidities, such as cancer and end-organ disease. With remaining challenges in terms of access to therapy, adherence and potential long-term drug toxicity, improving their long-term healthcare outcome, including new strategies for HIV clearance, remains a global priority. There is, therefore, an ongoing need to better characterize and harness the immune response in order to develop new strategies and supplement current therapeutic approaches for a "functional" cure. Current efforts toward HIV eradication to enhance immune recognition and elimination of persistently infected cells have highlighted the need for an optimized "kill" approach.

SUBMITTER: Alrubayyi A 

PROVIDER: S-EPMC7417314 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature