Re-evaluation of the Uplift Clinical Trial Using Age-Appropriate Spirometric Criteria.

ABSTRACT:

Background

The clinical trial of tiotropium in COPD, UPLIFT, enrolled adults with a mean age of 65 years and moderate-to-severe airflow obstruction, based on criteria from the Global Initiative for Chronic Obstructive Lung Disease (GOLD). For the UPLIFT cohort, however, GOLD-based criteria are not age-appropriate.

Research question

Will the use of more age-appropriate criteria for airflow obstruction from the Global Lung Function Initiative (GLI) modify the spirometric classification of the UPLIFT cohort and, in turn, the mortality effect of tiotropium in COPD?

Study design and methods

Baseline spirometric classifications were first cross-tabulated by GLI- and GOLD-based criteria. Next, in GLI- and GOLD-based airflow obstruction, modified intention-to-treat analyses e

SUBMITTER: Vaz Fragoso CA 

PROVIDER: S-EPMC7417373 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature