The Sleep Apnea-Specific Hypoxic Burden Predicts Incident Heart Failure.

ABSTRACT:

Background

Heart failure (HF) is a leading cause of morbidity and mortality and although it is linked to sleep apnea, which physiological stressors most strongly associate with incident disease is unclear. We tested whether sleep apnea-specific hypoxic burden (SASHB) predicts incident HF in two independent cohort studies.

Research question

In comparison with apnea-hypopnea index (AHI), how does sleep apnea-specific hypoxic burden predict incident HF?

Study design and methods

The samples were derived from two cohort studies: The Sleep Heart Health Study (SHHS), which included 4,881 middle-aged and older adults (54.4% women), age 63.6 ± 11.1 years; and the Outcomes of Sleep Disorders in Older Men (MrOS), which included 2,653 men, age 76.2 ± 5.4 years. We computed SASHB

SUBMITTER: Azarbarzin A 

PROVIDER: S-EPMC7417383 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature