MicroRNA-1281 as a Novel Circulating Biomarker in Patients With Diabetic Retinopathy.

ABSTRACT: Objective: Recently, the role of circulating miRNAs as non-invasive biomarkers for the identification and monitoring of diabetes microvascular complications has emerged. Herein, we aimed to: identify circulating miRNAs differentially expressed in patients with and without diabetic retinopathy (DR); examine their predictive value; and understand their pathogenic impact. Methods: Pooled serum samples from randomly selected matched patients with type 2 diabetes, either with or without DR, were used for initial serum miRNA profiling. Validation of the most relevant miRNAs was thereafter conducted by RT-qPCR in an extended sample of patients with DR and matched controls. Results: Following miRNA profiling, 43 miRNAs were significantly up- or down-regulated in patients with

SUBMITTER: Greco M 

PROVIDER: S-EPMC7417427 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature