Cross-talk between airway and gut microbiome links to IgE responses to house dust mites in childhood airway allergies.

ABSTRACT: A connection between airway and gut microbiota related to allergen exposure in childhood allergies was not well addressed. We aimed to identify the microbiota alterations in the airway and gut related to mite-specific IgE responses in young children with airway allergies. This study enrolled 60 children, including 38 mite-sensitized children (20 rhinitis and 18 asthma), and 22 non-mite-sensitized healthy controls. Microbiome composition analysis of the throat swab and stool samples was performed using bacterial 16S rRNA sequencing. An integrative analysis of the airway and stool microbial profiling associated with IgE reactions in childhood allergic rhinitis and asthma was examined. The Chao1 and Shannon indices in the airway were significantly lower than those in the stool. Additionally,

SUBMITTER: Chiu CY 

PROVIDER: S-EPMC7417544 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature