A three-tiered integrative analysis of transcriptional data reveals the shared pathways related to heart failure from different aetiologies.

ABSTRACT: Heart failure (HF) is the end stage of most heart disease cases and can be initiated from multiple aetiologies. However, whether the molecular basis of HF has a commonality between different aetiologies has not been elucidated. To address this lack, we performed a three-tiered analysis by integrating transcriptional data and pathway information to explore the commonalities of HF from different aetiologies. First, through differential expression analysis, we obtained 111 genes that were frequently differentially expressed in HF from 11 different aetiologies. Several genes, such as NPPA and NPPB, are early and accurate biomarkers for HF. We also provided candidates for further experimental verification, such as SERPINA3 and STAT4. Then, using gene set enrichment analysis, we successfully ide

SUBMITTER: Jiang Z 

PROVIDER: S-EPMC7417717 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature