Combination therapy of vitamin C and thiamine for septic shock: a multi-centre, double-blinded randomized, controlled study.

ABSTRACT:

Purpose

To evaluate the effects of early combination therapy with intravenous vitamin C and thiamine on recovery from organ failure in patients with septic shock.

Methods

The ascorbic acid and thiamine effect in septic shock (ATESS) trial was a multi-centre, double-blind, randomized, controlled trial conducted in four academic emergency departments, enrolling adult patients with septic shock from December 2018 through January 2020. Patients were randomly assigned in a 1:1 ratio to either the treatment group [intravenous vitamin C (50 mg/kg, maximum single dose 3 g) and thiamine (200 mg) administration every 12 h for a total of 48 h] or the placebo group (identical volume of 0.9% saline with the same protocol). The primary outcome was Δ Sequential Organ Failure Assessment (SO

SUBMITTER: Hwang SY 

PROVIDER: S-EPMC7417779 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature