Increased mortality in patients with severe SARS-CoV-2 infection admitted within seven days of disease onset.

ABSTRACT:

Purpose

Coronavirus disease 2019 (COVID-19) is creating an unprecedented healthcare crisis. Understanding the determinants of mortality is crucial to optimise intensive care unit (ICU) resource use and to identify targets for improving survival.

Methods

In a multicentre retrospective study, we included 379 COVID-19 patients admitted to four ICUs between 20 February and 24 April 2020 and categorised according to time from disease onset to ICU admission. A Cox proportional-hazards model identified factors associated with 28-day mortality.

Results

Median age was 66 years (53-68) and 292 (77%) were men. The main comorbidities included obesity and overweight (67%), hypertension (49.6%) and diabetes (30.1%). Median time from disease onset (i.e., viral symptoms) to ICU admis

SUBMITTER: Azoulay E 

PROVIDER: S-EPMC7417780 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature