Biomarkers of severity and threshold of allergic reactions during oral peanut challenges.

ABSTRACT:

Background

Oral food challenge (OFC) is the criterion standard to assess peanut allergy (PA), but it involves a risk of allergic reactions of unpredictable severity.

Objective

Our aim was to identify biomarkers for risk of severe reactions or low dose threshold during OFC to peanut.

Methods

We assessed Learning Early about Peanut Allergy study, Persistance of Oral Tolerance to Peanut study, and Peanut Allergy Sensitization study participants by administering the basophil activation test (BAT) and the skin prick test (SPT) and measuring the levels of peanut-specific IgE, Arachis hypogaea 2-specific IgE, and peanut-specific IgG4, and we analyzed the utility of the different biomarkers in relation to PA status, severity, and threshold dose of allergic reactions to peanut

SUBMITTER: Santos AF 

PROVIDER: S-EPMC7417812 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature