Structural analysis of experimental drugs binding to the SARS-CoV-2 target TMPRSS2.

ABSTRACT: The emergence of SARS-CoV-2 has prompted a worldwide health emergency. There is an urgent need for therapeutics, both through the repurposing of approved drugs and the development of new treatments. In addition to the viral drug targets, a number of human drug targets have been suggested. In theory, targeting human proteins should provide an advantage over targeting viral proteins in terms of drug resistance, which is commonly a problem in treating RNA viruses. This paper focuses on the human protein TMPRSS2, which supports coronavirus life cycles by cleaving viral spike proteins. The three-dimensional structure of TMPRSS2 is not known and so we have generated models of the TMPRSS2 in the apo state as well as in complex with a peptide substrate and putative inhibitors to aid future work. I

SUBMITTER: Huggins DJ 

PROVIDER: S-EPMC7417922 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature