Performance evaluation of serological assays to determine the immunoglobulin status in SARS-CoV-2 infected patients.

ABSTRACT:

Background

Serological assays for the determination of the immune status of patients that have tested positive for infection with SARS-CoV-2 by RT-PCR are required for, e.g., contact tracing and epidemiological studies. However, data concerning the performance parameters of commercially available high-throughput ELISA tests are still not available on a large scale.

Study design

In our study, we have evaluated an in-house developed ELISA for the detection of the immunoglobulin classes A, G and M directed against the full-length spike glycoprotein from SARS-CoV-2. For this analysis, we have included 110 sera from patients presenting with COVID-19 symptoms or blood donors without symptoms collected at the Austrian Red Cross, Blood Transfusion Service for Upper Austria, Linz. In

SUBMITTER: Wechselberger C 

PROVIDER: S-EPMC7417972 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature