Transcriptome sequencing supports a conservation of macrophage polarization in fish.

ABSTRACT: Mammalian macrophages can adopt polarization states that, depending on the exact stimuli present in their extracellular environment, can lead to very different functions. Although these different polarization states have been shown primarily for macrophages of humans and mice, it is likely that polarized macrophages with corresponding phenotypes exist across mammals. Evidence of functional conservation in macrophages from teleost fish suggests that the same, or at least comparable polarization states should also be present in teleosts. However, corresponding transcriptional profiles of marker genes have not been reported thus far. In this study we confirm that macrophages from common carp can polarize into M1- and M2 phenotypes with conserved functions and corresponding transcriptional pro

SUBMITTER: Wentzel AS 

PROVIDER: S-EPMC7418020 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature