Intraarticular injection of liposomal adenosine reduces cartilage damage in established murine and rat models of osteoarthritis.

ABSTRACT: Osteoarthritis (OA) affects nearly 10% of the population of the United States and other industrialized countries and, at present, short of surgical joint replacement, there is no therapy available that can reverse the progression of the disease. Adenosine, acting at its A2A receptor (A2AR), is a critical autocrine factor for maintenance of cartilage homeostasis and here we report that injection of liposomal suspensions of either adenosine or a selective A2AR agonist, CGS21680, significantly reduced OA cartilage damage in a murine model of obesity-induced OA. The same treatment also improved swelling and preserved cartilage in the affected knees in a rat model of established post-traumatic OA (PTOA). Differential expression analysis of mRNA from chondrocytes harvested from knees of rats wit

SUBMITTER: Corciulo C 

PROVIDER: S-EPMC7418027 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature