Estimating the Heritability of Structural and Functional Brain Connectivity in Families Affected by Attention-Deficit/Hyperactivity Disorder.

ABSTRACT:

Importance

Despite its high heritability, few risk genes have been identified for attention-deficit/hyperactivity disorder (ADHD). Brain-based phenotypes could aid gene discovery. There is a myriad of structural and functional connections that support cognition. Disruption of such connectivity is a key pathophysiologic mechanism for ADHD, and identifying heritable phenotypes within these connections could provide candidates for genomic studies.

Objective

To identify the structural and functional connections that are heritable and pertinent to ADHD.

Design, setting, and participants

Members of extended multigenerational families enriched for ADHD were evaluated. Structural connectivity was defined by diffusion tensor imaging (DTI) of white matter tract microstructure a

SUBMITTER: Sudre G 

PROVIDER: S-EPMC7418037 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature