Clinical Predictors of Neurotoxicity After Chimeric Antigen Receptor T-Cell Therapy.

ABSTRACT:

Importance

Chimeric antigen receptor (CAR) T-cell therapy for relapsed or refractory hematologic malignant neoplasm causes severe neurologic adverse events ranging from encephalopathy and aphasia to cerebral edema and death. The cause of neurotoxicity is incompletely understood, and its unpredictability is a reason for prolonged hospitalization after CAR T-cell infusion.

Objective

To identify clinical and laboratory parameters predictive of neurotoxicity and to develop a prognostic score associated with its risk.

Design, setting, and participants

This single-center diagnostic/prognostic accuracy study was conducted at Brigham and Women's Hospital/Dana Farber Cancer Institute from April 2015 to February 2020. A consecutive sample of all patients undergoing CAR T-cell t

SUBMITTER: Rubin DB 

PROVIDER: S-EPMC7418044 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature