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Activation of adenosine A_2A but not A_2B receptors is involved in uridine adenosine tetraphosphate-induced porcine coronary smooth muscle relaxation.

ABSTRACT: Activation of both adenosine A_2A and A_2B receptors (A_2BR) contributes to coronary vasodilation. We previously demonstrated that uridine adenosine tetraphosphate (Up₄A) is a novel vasodilator in the porcine coronary microcirculation, acting mainly on A_2AR in smooth muscle cells (SMC). We further investigated whether activation of A_2BR is involved in Up₄A-mediated coronary SMC relaxation. Both A_2AR and A_2BR may stimulate H₂O₂ production leading to activation of K_ATP channels in SMCs, we also studied the involvement of H₂O₂ and K_ATP channels in Up₄A-mediated effect. Coronary small arteries dissected from the apex of por

SUBMITTER: Sun C

PROVIDER: S-EPMC7418061 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Activation of adenosine A_2A but not A_2B receptors is involved in uridine adenosine tetraphosphate-induced porcine coronary smooth muscle relaxation.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Activation of adenosine A2A but not A2B receptors is involved in uridine adenosine tetraphosphate-induced porcine coronary smooth muscle relaxation.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Activation of adenosine A_2A but not A_2B receptors is involved in uridine adenosine tetraphosphate-induced porcine coronary smooth muscle relaxation.