Trends in excess mortality associated with atrial fibrillation over 45 years (Framingham Heart Study): community based cohort study.

ABSTRACT: OBJECTIVE:To assess temporal trends in the association between newly diagnosed atrial fibrillation and death. DESIGN:Community based cohort study. SETTING:Framingham Heart Study cohort, in 1972-85, 1986-2000, and 2001-15 (periods 1-3, respectively), in Framingham, MA, USA. PARTICIPANTS:Participants with no atrial fibrillation, aged 45-95 in each time period, and identified with newly diagnosed atrial fibrillation (or atrial flutter) during each time period. MAIN OUTCOME MEASURES:The main outcome was all cause mortality. Hazard ratios for the association between time varying atrial fibrillation and all cause mortality were calculated with adjustment for time varying confounding factors. The difference in restricted mean survival times, adjusted for confounders, between participants with atr

SUBMITTER: Vinter N 

PROVIDER: S-EPMC7418071 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature