Design, synthesis and application of carbazole macrocycles in anion sensors.

ABSTRACT: Carboxylate sensing solid-contact ion-selective electrodes (ISEs) were created to provide a proof-of-concept ISE development process covering all aspects from in silico ionophore design to functional sensor characterization. The biscarbazolylurea moiety was used to synthesize methylene-bridged macrocycles of different ring size aiming to fine tune selectivity towards different carboxylates. Cyclization was achieved with two separate strategies, using either amide synthesis to access up to -[CH₂]₁₀- macrocycles or acyl halides to access up to -[CH₂]₁₄- macrocycles. Seventy-five receptor-anion complexes were modelled and studied with COSMO-RS, in addition to all free host molecules. In order to predict initial selectivity towards carboxylates,

SUBMITTER: Ruutel A 

PROVIDER: S-EPMC7418101 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature