Polymorphism of XRCC3 in Egyptian Breast Cancer Patients.

ABSTRACT:

Purpose

Polymorphisms of DNA repair genes may contribute to variations in DNA repair capacity and subsequent genetic susceptibility to different cancers. In Egypt, breast cancer is the most common cancer among women, representing 18.9% of the total cancer cases. The present study assesses the correlation between X-ray repair cross-complementing group 3 (XRCC3) polymorphism with breast cancer and treatment response in Egyptian female breast cancer patients.

Patients and methods

This pilot case-control study was conducted on 66 female breast cancer patients and 20 apparently healthy females as a control group. Tumor grading, immunohistostaining of hormone (progesterone and estrogen) receptors and human epidermal growth factor receptor 2 (HER2), and RFLP-PCR for XRCC3

SUBMITTER: Alkasaby MK 

PROVIDER: S-EPMC7418173 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature