Fecal DNA methylation markers for detecting stages of colorectal cancer and its precursors: a systematic review.

ABSTRACT:

Background

DNA methylation biomarkers in stool may have applications in early colorectal cancer (CRC) detection; however, their association with stages of CRC carcinogenesis or their performance in detecting various stages is unclear. We aimed to systematically review the evidence for DNA methylation markers in stool for risk stratification or detection of specific CRC stages, as well as precursors of CRC.

Methods

We conducted a systematic search in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We searched PubMed and ISI Web of Knowledge to identify relevant studies published until 14th January 2020. Two reviewers independently extracted data on study population characteristics, candidate genes, methylation measurement methods,

SUBMITTER: Raut JR 

PROVIDER: S-EPMC7418412 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature