Determinants and prognostic value of echocardiographic first-phase ejection fraction in aortic stenosis.

ABSTRACT:

Objective

First-phase ejection fraction (EF1) is a novel measure of early left ventricular systolic dysfunction. We investigated determinants of EF1 and its prognostic value in aortic stenosis.

Methods

EF1 was measured retrospectively in participants of an echocardiography/cardiovascular magnetic resonance cohort study which recruited patients with aortic stenosis (peak aortic velocity of ≥2 m/s) between 2012 and 2014. Linear regression models were constructed to examine variables associated with EF1. Cox proportional hazards were used to determine the prognostic power of EF1 for aortic valve replacement (AVR, performed as part of clinical care in accordance with international guidelines) or death.

Results

Total follow-up of the 149 participants (69.8% male, 70 (65-76

SUBMITTER: Bing R 

PROVIDER: S-EPMC7418600 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature