Enhancing natriuretic peptide signaling in adipose tissue, but not in muscle, protects against diet-induced obesity and insulin resistance.

ABSTRACT: In addition to controlling blood pressure, cardiac natriuretic peptides (NPs) can stimulate lipolysis in adipocytes and promote the "browning" of white adipose tissue. NPs may also increase the oxidative capacity of skeletal muscle. To unravel the contribution of NP-stimulated metabolism in adipose tissue compared to that in muscle in vivo, we generated mice with tissue-specific deletion of the NP clearance receptor, NPRC, in adipose tissue (Nprc^AKO ) or in skeletal muscle (Nprc^MKO ). We showed that, similar to Nprc null mice, Nprc^AKO mice, but not Nprc^MKO mice, were resistant to obesity induced by a high-fat diet. Nprc^AKO mice exhibited increased energy expen

SUBMITTER: Wu W 

PROVIDER: S-EPMC7418652 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature