CD163⁺ cytokine-producing cDC2 stimulate intratumoral type 1 T cell responses in HPV16-induced oropharyngeal cancer.

ABSTRACT:

Background

Human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) is a distinct clinical entity with a much better prognosis after (chemo)radiotherapy than HPV-negative OPSCC, especially in patients with a concomitant intratumoral HPV-specific and type-1 cytokine-oriented T cell response. However, knowledge on the type of myeloid cells and their coordination with intratumoral T cells and influence on patient outcome in OPSCC is lacking.

Methods

We analyzed the presence of intratumoral myeloid cells and their relationship to tumor-infiltrating T cells and patient outcome in a well-described cohort of HPV16⁺ patients with OPSCC using multispectral immunofluorescence, flow cytometry and functional analyses.

Results

We show that the

SUBMITTER: Santegoets SJ 

PROVIDER: S-EPMC7418847 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature