Surgical treatment for heart failure: cell-based therapy with engineered tissue.

ABSTRACT: This review will outline cell-based therapy for heart failure focusing on tissue engineering to deliver cells to the damaged heart. We will present an overview of the central approaches focusing on pluripotent stem cell-derived cells, mechanisms of action, autologous vs. allogeneic cell approaches, immunologic modulation, and safety considerations. We will outline the progress that has been made to-date and define the areas that still need to be investigated in order to advance the field.

SUBMITTER: Lancaster JJ 

PROVIDER: S-EPMC7418896 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature