Silent NK/T cell reactions to dasatinib during sustained deep molecular response before cessation are associated with longer treatment-free remission.

ABSTRACT: This study presents the final report of the multicenter, prospective tyrosine kinase inhibitor discontinuation study, D-STOP, after a 3-year follow-up of 54 patients with chronic CML who discontinued dasatinib after a sustained deep molecular response (DMR) for ≥2 years with dasatinib treatment. Estimated treatment-free remission (TFR) rates at 12 and 36 months were 63.0% [95% confidence interval (CI): 48.7-74.3] and 59.3% (95% CI: 45.0-71.0), respectively. CD3^- CD56⁺ NK, CD16⁺ CD56⁺ NK, and CD57⁺ CD56⁺ NK large granular lymphocyte (NK-LGL), CD8⁺ CD4^- cytotoxic T cell, and CD57⁺ CD3⁺ T-LGL cell numbers were relatively elevated throughout the 24-month consolidation only in failed pa

SUBMITTER: Kumagai T 

PROVIDER: S-EPMC7419041 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature