Androgen Receptor mRNA levels determine the prognosis in triple-negative breast cancer patients.

ABSTRACT:

Background

Anti-Androgen Receptor (AR) therapy holds promise for a subset of AR expressing triple-negative breast cancer (TNBC) patients. However, current AR assays are suboptimal in detecting the dynamic range of AR expression, contributing to its controversial role in TNBC disease prognosis. This study is aimed at evaluating the feasibility of qRT-PCR to sensitively and robustly detect AR mRNA levels for prognostication.

Methods

mRNA expression profiling was performed on FFPE blocks from a retrospective cohort of 101 TNBC patients using qRT-PCR and compared with AR protein expression by immunohistochemistry . Statistical analyses included Spearman's rank correlation, Chi-square and Kaplan-Meier analyses. Distant Metastasis Free Survival was used as the end point in surviva

SUBMITTER: Govindan S 

PROVIDER: S-EPMC7419184 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature