Motivation and sensitivity to monetary reward in late-life insomnia: moderating role of sex and the inflammatory marker CRP.

ABSTRACT: Insomnia is a well-established risk factor for late-life depression, yet the intermediary mechanisms are not known. One plausible mechanism is dysregulation of the reward system, a common feature of depression. The main objective of the current study was to determine whether late-life insomnia is associated with reduced motivation and reduced sensitivity for monetary reward. Secondary exploratory objectives were to test for sex-specific effects and whether elevated inflammation potentiated these associations. Nondepressed community dwelling older adults (n = 104; aged 60-80) who either met (n = 31) or did not meet (n = 73) criteria for insomnia disorder as assessed by the Structured Clinical Interview for DSM-5 completed the Effort Expenditure for Rewards Task and provided blood samples fo

SUBMITTER: Boyle CC 

PROVIDER: S-EPMC7419294 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature