Association between periodontal disease and vulnerable plaque morphology in patients undergoing carotid endarterectomy.

ABSTRACT:

Background

Periodontal disease (PD) is a chronic inflammatory oral condition with potentially important systemic sequelae. We sought to determine whether the presence of PD in patients with severe carotid disease was associated with morphological features consistent with carotid plaque instability.

Methods

A total of 52 dentate patients hospitalized for carotid endarterectomy (CEA) had standardized assessments of their periodontal status, including measurements of probing pocket depth (PPD), clinical attachment level (CAL) and bleeding on probing (BoP). Carotid plaque morphology was assessed by ultrasound using the gray scale median (GSM) score and by immunohistochemistry using anti-CD68 and anti-alpha-actin antibodies, markers for macrophages and smooth muscle cells (SMCs)

SUBMITTER: Bobetsis YA 

PROVIDER: S-EPMC7419330 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature