Endogenous activity modulates stimulus and circuit-specific neural tuning and predicts perceptual behavior.

ABSTRACT: Perception reflects not only sensory inputs, but also the endogenous state when these inputs enter the brain. Prior studies show that endogenous neural states influence stimulus processing through non-specific, global mechanisms, such as spontaneous fluctuations of arousal. It is unclear if endogenous activity influences circuit and stimulus-specific processing and behavior as well. Here we use intracranial recordings from 30 pre-surgical epilepsy patients to show that patterns of endogenous activity are related to the strength of trial-by-trial neural tuning in different visual category-selective neural circuits. The same aspects of the endogenous activity that relate to tuning in a particular neural circuit also correlate to behavioral reaction times only for stimuli from the category th

SUBMITTER: Li Y 

PROVIDER: S-EPMC7419548 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature