Arachidonic Acid Promotes Intestinal Regeneration by Activating WNT Signaling.

ABSTRACT: Intestinal regeneration is crucial for functional restoration after injury, and nutritional molecules can play an important role in this process. Here, we found that arachidonic acid (AA) serves as a direct proliferation promoter of intestinal epithelial cells that facilitates small intestinal regeneration in both three-dimensional cultured organoids and mouse models. As shown in the study, during post-irradiation regeneration, AA positively regulates intestinal epithelial cell proliferation by upregulating the expression of Ascl2 and activating WNT signaling, but negatively regulates intestinal epithelial cell differentiation. AA acts as a delicate regulator that efficiently facilitates epithelial tissue repair by activating radiation-resistant Msi1⁺ cells rather than Lgr5

SUBMITTER: Wang Q 

PROVIDER: S-EPMC7419670 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature