Association of particulate matter air pollution with leukocyte mitochondrial DNA copy number.

ABSTRACT:

Background

Ambient particulate matter (PM) has been associated with mitochondrial damage and dysfunction caused by excessive oxidative stress, but the associations between long-term PM exposure and leukocyte mitochondrial DNA copy number (mtDNAcn), a biomarker of mitochondrial dysfunction due to oxidative stress, are less studied.

Objectives

To investigate the associations between short-, intermediate- and long-term exposure (1-, 3- and 12-months) to different size fractions of PM (PM_2.5, PM_2.5-10 and PM₁₀) and leukocyte mtDNAcn in a cross-sectional study.

Methods

The associations between each of the PM exposure metrics with z scores of log-transformed mtDNAcn were examined using generalized linear regression models in 2758 female part

SUBMITTER: Wang X 

PROVIDER: S-EPMC7419671 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature