A Neglected Topic in Neuroscience: Replicability of fMRI Results With Specific Reference to ANOREXIA NERVOSA.

ABSTRACT: Functional magnetic resonance imaging (fMRI) studies report impaired functional correlates of cognition and emotion in mental disorders. The validity of preexisting studies needs to be confirmed through replication studies, which there is a lack of. So far, most replication studies have been conducted on non-patients (NP) and primarily investigated cognitive and motor tasks. To fill this gap, we conducted the first fMRI replication study to investigate brain function using disease-related food stimuli in patients with anorexia nervosa (AN). Using fMRI, we investigated 31 AN patients and 27 NP for increased amygdala and reduced midcingulate activation when viewing food and non-food stimuli, as reported by the original study (11AN, 11NP; Joos et al., 2011). Similar to the previous study, we

SUBMITTER: Horster I 

PROVIDER: S-EPMC7419696 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature