Ontology highlight
ABSTRACT:
SUBMITTER: Sarmiento-Castro A
PROVIDER: S-EPMC7419713 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Stem cell reports 20200723 2
Estrogen-receptor-positive breast tumors are treated with anti-estrogen (AE) therapies but frequently develop resistance. Cancer stem cells (CSCs) with high aldehyde dehydrogenase activity (ALDH<sup>+</sup> cells) are enriched following AE treatment. Here, we show that the interleukin-1β (IL-1β) signaling pathway is activated in ALDH<sup>+</sup> cells, and data from single cells reveals that AE treatment selects for IL-1 receptor (IL1R1)-expressing ALDH<sup>+</sup> cells. Importantly, CSC activi ...[more]