Structural-functional decoupling predicts suicide attempts in bipolar disorder patients with a current major depressive episode.

ABSTRACT: Bipolar disorder (BD) is associated with a high risk of suicidality, and it is challenging to predict suicide attempts in clinical practice to date. Although structural and functional connectivity alterations from neuroimaging studies have been previously reported in BD with suicide attempts, little is known about how abnormal structural and functional connectivity relates to each other. Here, we hypothesize that structure connectivity constrains functional connectivity, and structural-functional coupling is a more sensitive biomarker to detect subtle brain abnormalities than any single modality in BD patients with a current major depressive episode who had attempted suicide. By investigating structural and resting-state fMRI connectivity, as well as their coupling among 191 BD depression

SUBMITTER: Jiang H 

PROVIDER: S-EPMC7421902 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature