GENESIS: Phase III trial evaluating BL-8040 + G-CSF to mobilize hematopoietic cells for autologous transplant in myeloma.

ABSTRACT: Effective hematopoietic cell transplantation relies upon collecting adequate numbers of CD34⁺ hematopoietic stem cells, typically from peripheral blood. A minimum of ≥2 × 10⁶ CD34⁺ cells/kg are necessary, while transplants of ≥5-6 × 10⁶ CD34⁺ cells/kg are associated with improved hematopoietic recovery. Granulocyte colony stimulating factor (G-CSF) remains the gold standard for hematopoietic stem cell mobilization. However, in randomized trials for autologous-hematopoietic cell transplantation in multiple myeloma, approximately 45% of patients remain unable to optimally mobilize with G-CSF alone despite multiple injections and apheresis days. Therefore, reducing mobilization failures remains an unmet need. The study objective is to eva

SUBMITTER: Crees ZD 

PROVIDER: S-EPMC7421992 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature