Genetic variants in epithelial-mesenchymal transition genes as predictors of clinical outcomes in localized prostate cancer.

ABSTRACT:

Background

Epithelial-mesenchymal transition (EMT) plays a pivotal role in the progression of prostate cancer (PCa). However, little is known about genetic variants in the EMT pathway as predictors of aggressiveness, biochemical recurrence (BCR) and disease reclassification in localized PCa.

Patients and methods

In this multistage study, we evaluated 5186 single nucleotide polymorphisms (SNPs) from 264 genes related to EMT pathway to identify SNPs associated with PCa aggressiveness and BCR in the MD Anderson PCa (MDA-PCa) patient cohort (N = 1762), followed by assessment of the identified SNPs with disease reclassification in the active surveillance (AS) cohort (N = 392).

Results

In the MDA-PCa cohort, 312 SNPs were associated with high D'Amico risk (P < 0.05), among

SUBMITTER: Deng Y 

PROVIDER: S-EPMC7422619 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature