IL-6 regulates CCR5 expression and immunosuppressive capacity of MDSC in murine melanoma.

ABSTRACT:

Background

Myeloid-derived suppressor cells (MDSC) play a major role in the immunosuppressive melanoma microenvironment. They are generated under chronic inflammatory conditions characterized by the constant production of inflammatory cytokines, chemokines and growth factors, including IL-6. Recruitment of MDSC to the tumor is mediated by the interaction between chemokines and chemokine receptors, in particular C-C chemokine receptor (CCR)5. Here, we studied the mechanisms of CCR5 upregulation and increased immunosuppressive function of CCR5⁺ MDSC.

Methods

The immortalized myeloid suppressor cell line MSC-2, primary immature myeloid cells and in vitro differentiated MDSC were used to determine factors and molecular mechanisms regulating CCR5 expression and immunos

SUBMITTER: Weber R 

PROVIDER: S-EPMC7422659 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature