Early steroid pulse therapy among children with influenza virus-associated encephalopathy.

ABSTRACT:

Background

Influenza virus-associated encephalopathy (IAE) can lead to neurological sequela and mortality among children. Therefore, instant recognition and therapeutic intervention for IAE are crucial. In some clinical subtypes of IAE, steroid pulse therapy might be beneficial, especially when it is administered in the early phase. However, early identification of patients who may benefit from steroid pulse therapy is sometimes difficult. We aimed to assess the effectiveness of early steroid pulse therapy among children with IAE.

Methods

In this retrospective observational study, we used a national database that covers half of the acute care inpatients across Japan to identify inpatients aged ≤ 18 years with a diagnosis of IAE between July 2010 and March 2017. Unfavorable o

SUBMITTER: Hatachi T 

PROVIDER: S-EPMC7422675 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature