Organ System Network Disruption Is Associated With Poor Prognosis in Patients With Chronic Liver Failure.

ABSTRACT:

Background

A healthy individual has a high degree of functional connectivity between organ systems, which can be represented graphically in a network map. Disruption of this system connectivity is associated with mortality in life-threatening acute illnesses, demonstrated by a network approach. However, this approach has not been applied to chronic multisystem diseases and may be more reliable than conventional individual organ prognostic scoring methods. Cirrhosis is a chronic disease of the liver with multisystem involvement. Development of an efficient model for prediction of mortality in cirrhosis requires a profound understanding of the pathophysiologic processes that lead to poor prognosis. In the present study, we use a network approach to evaluate the differences in organ s

SUBMITTER: Tan YY 

PROVIDER: S-EPMC7422730 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature