Microporous Drug Delivery System for Sustained Anti-VEGF Delivery to the Eye.

ABSTRACT:

Purpose

To describe a novel microporous drug delivery system (DDS) for sustained anti- vascular endothelial growth factor (VEGF) delivery to the eye and to evaluate its efficacy in a corneal injury model.

Methods

A macro-porous DDS (1.5 × 1.5 × 4 mm) loaded with 2 mg of bevacizumab was implanted subconjunctivally in three Dutch-belted pigmented rabbits after corneal alkali injury (2N NaOH). Three rabbits received sham DDS. Animals were followed for three months and assessed in vivo and ex vivo for corneal neovascularization (NV), epithelial defect, stromal scarring, endothelial cell loss, and expression of angiogenic and inflammatory markers in the cornea and retina.

Results

Anti-VEGF DDS treatment led to complete inhibition of superior cornea NV and complete corneal

SUBMITTER: Zhou C 

PROVIDER: S-EPMC7422759 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature