Characterization of a Murine Model of Oxazolone-Induced Orbital Inflammation.

ABSTRACT:

Purpose

Acute orbital inflammation can lead to irreversible vision loss in serious cases. Treatment thus far has been limited to systemic steroids or surgical decompression of the orbit. An animal model that mimics the characteristic features of acute orbital inflammation as found in thyroid eye disease can be used to explore novel treatment modalities.

Methods

We developed a murine model of orbital inflammation by injecting oxazolone into the mouse orbit. The mice underwent magnetic resonance imaging (MRI) and were euthanized at various time points for histologic examination. Immunofluorescence studies of specific inflammatory cells and cytokine arrays were performed.

Results

We found clinical and radiographic congruity between the murine model and human disease. Aft

SUBMITTER: Amarnani D 

PROVIDER: S-EPMC7422768 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature