Antimycotic Activity of Ozonized Oil in Liposome Eye Drops against Candida spp.

ABSTRACT:

Purpose

This study aims to investigate the antifungal activity and mechanism of action of ozonized oil eye drops in liposomes (Ozodrop), commercialized as eye lubricant for the treatment of dry eye syndrome and eye inflammation. The activity was tested against four clinical Candida species: C albicans, C glabrata, C krusei, and C orthopsilosis.

Methods

The antifungal activity of the eye drop solution was ascertained by microdilution method in accordance with EUCAST obtaining the minimum inhibitory concentration for Ozodrop. The mechanism of action was further investigated in C albicans by measuring cell vitality, intracellular reactive oxygen species production, levels of cellular and mitochondrial

SUBMITTER: Celenza G 

PROVIDER: S-EPMC7422790 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature