Hypoxia inducible factor-1α knockout does not impair acute thermal tolerance or heat hardening in zebrafish.

ABSTRACT: The rapid increase in critical thermal maximum (CT_max) in fish (or other animals) previously exposed to critically high temperature is termed 'heat hardening', which likely represents a key strategy to cope with increasingly extreme environments. The physiological mechanisms that determine acute thermal tolerance, and the underlying pathways facilitating heat hardening, remain debated. It has been posited, however, that exposure to high temperature is associated with tissue hypoxia and may be associated with the increased expression of hypoxia-inducible factor-1 (Hif-1). We studied acute thermal tolerance in zebrafish (Danio rerio) lacking functional Hif-1α paralogs (Hif-1aa and Hif-1ab double knockout; Hif-1α^-/-), which are known to exhibit marke

SUBMITTER: Joyce W 

PROVIDER: S-EPMC7423049 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature