A chemical interpretation of protein electron density maps in the worldwide protein data bank.

ABSTRACT: High-quality three-dimensional structural data is of great value for the functional interpretation of biomacromolecules, especially proteins; however, structural quality varies greatly across the entries in the worldwide Protein Data Bank (wwPDB). Since 2008, the wwPDB has required the inclusion of structure factors with the deposition of x-ray crystallographic structures to support the independent evaluation of structures with respect to the underlying experimental data used to derive those structures. However, interpreting the discrepancies between the structural model and its underlying electron density data is difficult, since derived sigma-scaled electron density maps use arbitrary electron density units which are inconsistent between maps from different wwPDB entries. Therefore, we h

SUBMITTER: Yao S 

PROVIDER: S-EPMC7423092 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature