Cortical ignition dynamics is tightly linked to the core organisation of the human connectome.

ABSTRACT: The capability of cortical regions to flexibly sustain an "ignited" state of activity has been discussed in relation to conscious perception or hierarchical information processing. Here, we investigate how the intrinsic propensity of different regions to get ignited is determined by the specific topological organisation of the structural connectome. More specifically, we simulated the resting-state dynamics of mean-field whole-brain models and assessed how dynamic multistability and ignition differ between a reference model embedding a realistic human connectome, and alternative models based on a variety of randomised connectome ensembles. We found that the strength of global excitation needed to first trigger ignition in a subset of regions is substantially smaller for the model embedding

SUBMITTER: Castro S 

PROVIDER: S-EPMC7423150 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature