Hepatocyte peroxisome proliferator-activated receptor α regulates bile acid synthesis and transport.

ABSTRACT: Peroxisome proliferator-activated receptor alpha (PPARα) controls lipid homeostasis through regulation of lipid transport and catabolism. PPARα activators are clinically used for hyperlipidemia treatment. The role of PPARα in bile acid (BA) homeostasis is beginning to emerge. Herein, Ppara-null and hepatocyte-specific Ppara-null (Ppara^∆Hep) as well as the respective wild-type mice were treated with the potent PPARα agonist Wy-14,643 (Wy) and global metabolomics performed to clarify the role of hepatocyte PPARα in the regulation of BA homeostasis. Levels of all serum BAs were markedly elevated in Wy-treated wild-type mice but not in Ppara-null and Ppara^∆Hep mice. Gene expression analysis showed that PPARα activation (1) down-regulated the expression of sodium-taurochol

SUBMITTER: Xie C 

PROVIDER: S-EPMC7423166 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature