Dataset Information

The biophysical, molecular, and anatomical landscape of pigeon CRY4: A candidate light-based quantal magnetosensor.

ABSTRACT: The biophysical and molecular mechanisms that enable animals to detect magnetic fields are unknown. It has been proposed that birds have a light-dependent magnetic compass that relies on the formation of radical pairs within cryptochrome molecules. Using spectroscopic methods, we show that pigeon cryptochrome clCRY4 is photoreduced efficiently and forms long-lived spin-correlated radical pairs via a tetrad of tryptophan residues. We report that clCRY4 is broadly and stably expressed within the retina but enriched at synapses in the outer plexiform layer in a repetitive manner. A proteomic survey for retinal-specific clCRY4 interactors identified molecules that are involved in receptor signaling, including glutamate receptor-interacting protein 2, which colocalizes with clCRY4. Our data support a model whereby clCRY4 acts as an ultraviolet-blue photoreceptor and/or a light-dependent magnetosensor by modulating glutamatergic synapses between horizontal cells and cones.

SUBMITTER: Hochstoeger T

PROVIDER: S-EPMC7423367 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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The biophysical, molecular, and anatomical landscape of pigeon CRY4: A candidate light-based quantal magnetosensor.

Hochstoeger Tobias T Al Said Tarek T Maestre Dante D Walter Florian F Vilceanu Alexandra A Pedron Miriam M Cushion Thomas D TD Snider William W Nimpf Simon S Nordmann Gregory Charles GC Landler Lukas L Edelman Nathaniel N Kruppa Lennard L Dürnberger Gerhard G Mechtler Karl K Schuechner Stefan S Ogris Egon E Malkemper E Pascal EP Weber Stefan S Schleicher Erik E Keays David A DA

Science advances 20200812 33

The biophysical and molecular mechanisms that enable animals to detect magnetic fields are unknown. It has been proposed that birds have a light-dependent magnetic compass that relies on the formation of radical pairs within cryptochrome molecules. Using spectroscopic methods, we show that pigeon cryptochrome clCRY4 is photoreduced efficiently and forms long-lived spin-correlated radical pairs via a tetrad of tryptophan residues. We report that clCRY4 is broadly and stably expressed within the r ...[more]

PMID: 32851187

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Dataset Information

The biophysical, molecular, and anatomical landscape of pigeon CRY4: A candidate light-based quantal magnetosensor.

Publications

The biophysical, molecular, and anatomical landscape of pigeon CRY4: A candidate light-based quantal magnetosensor.

Similar Datasets

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